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Polypharmacy, the concurrent use of several drugs, increases the risk of adverse drug reactions and interactions in older adults. Besides adverse drug reactions and drug-drug interactions, other clinical consequences of polypharmacy include nonadherence, unintentional overdose, increased risk of hospitalizations, and medication errors. While taking more than two drugs can increase the risk of an adverse effect, taking more than five drugs boosts that risk. As the number of drugs taken and the age of the person increase, so does the risk for adverse drug interactions. This module describes the polypharmacy problem, why it occurs, and ways to address it.